Why would you want to ignore reversed graphics?

Hello,

I reversed some buttons because I liked the way the images on them fit into the scene better in that position. However, when I reversed the buttons they were no longer clickable. I unchecked "ignore reversed graphics" on the canvas and now it works again. I just want to make sure that this won't be an issue down the line so can you please tell me in which scenarios would you WANT to ignore reversed graphics? When would this be useful?

Thanks,