Upload mesh data into VRAM and re-use it for redraw via manual draw commands?

So specific reasons I'm using DrawMesh to submit some meshes fore rendering manually at the end of a frame. The issue is, since meshes are allocated on RAM, every time I issue this command it is being copied via PCI bus from RAM to VRAM and so on each frame. That's not ideal, as you can imagine.
I have 3 types of meshes:

1. Static complex meshes
2. Dynamic cube, can change size and rotation and position
3. Sphere, can change size and position

Now my question is: can I pre-upload case 1 to VRAM and then use returned handle to issue draw commands to draw from existing memory? Is it possible to do the same for 2 and 3 using some on-GPU transformations?