UnityWebRequest not working on Windows 10 -Sometimes

I'm stumped by an issue I can't recreate, but over 25% of my users are experiencing. Through some debugging I was able to determine UnityWebRequest is never getting a response. However I have 5 Win 10 PCs and was never able to replicate it.

The users that have the issues are able to get to the URLs via their browsers with no problem.

It appears that something is blocking web traffic from the app, but I've validated it's not windows defender, and the users say they have nothing else that would block it.

I cannot imagine how this could be an issue in UnityWebRequest, but being at my wits end, I wanted to post here to see if anyone had some insight.

Thanks!