Question Two Bone IK Constraint brakes hands/ankles

Hi,

I wanted to add feet and hand adjustments using new animation rigging. The system as the system works fine, but, when I add Two Bone IK Constraint to for example, the left arm, using wrist as Tip, forearm as Mid and shoulder as Root the whole fist brakes and starts pointing upwards and I cant manually rotate it in the editor while the game is running.

 

Same problem. I even removed all animations and the figure squats when I play.