1) What happened? Nested UI canvases do not seem to retain their anchoring settings (as set by the rect transform component) upon saving->reopening or hitting play. This bug is new as of either 4.6.1 or 4.6.2. Everything was perfect in 4.6.0! 2) How can we reproduce it using the example you attached? CanvasNested is a child of Canvas. If you try to modify the anchor preset of CanvasNested in any way, and then hit play, it will always reset to "bottom left" and be really wonky in general. (Submitted as issue 671550) I wish I could find some workaround for this issue beyond recreating everything, it has really messed up my game's menus!