Many Prefabs Problem. Need advice

Hi, im new to coding not sure what is the correct way to do. My game consists a total of 6 color buttons. Each button contains a total of 6 possible correct answer . Which have a grand totaal of 36 prefabs. Start of game 1 random prefabs appears on the screen. Then after button is pressed want to change the prefabs to another one from the index 36 prefabs. I need some pointers or advice how to go . I plan on using a Pool Collection to recycle prefabs and instantiate new prefabs when buttton is click...?