Hello, i don't know if i'm doing something wrong but i would definitly say it's a bug and i'm surprised i couldn't find any thread about it. I've tested it on 2020.2.3f1 and 2019.4.18f1 I have a simple animator with just a default state which scale up the panel. If I just hit "run" with the gameobject enabled, the animation will not be played, i'm right away set at the end of the default state. preview On the other hand, if i hit "run" with the gameobject disabled, then i enable it, the animation is properly played. preview I feel there are conflicts between the initialization of the animator and the project itself.