Changing Quality Settings at Runtime is Resetting Saturation Levels?

We dynamically desaturate the screen when the player is low on health, as I'm sure you've seen in other games. The only problem is, if the player changes the graphics tier while the screen is de-saturated, it will reset the saturation to default. I assume this is due to the saturation being dynamic, instead of the global saturation levels set in editor? Is there a way to prevent this, or does the saturation just need to be re-applied after the graphics are updated?