Change hierarchy and remove any assets in remote addressable

I have two questions:

1 - I have for example a canvas of a store system in my game like:

- CANVAS
- - Store Panel
- - - Item 1
- - - Item 2
- - - Item 3

But if I change the hierarchy as:

- CANVAS
- - Store Panel
- - - Items Panel
- - - - Item 1
- - - - Item 2
- - - - Item 3

How could I update this in remote addressable? Would it be correct for me to mark the entire canvas as addressable? Or is there any other way to change hierarchies and update my game via remote addressable?

2 - How could I remove some asset and thus update via remote addressable, causing my players game to update by removing some asset instead of updating it by changing the asset? In the case as in the example above I remove Item 2 from the Items Panel, then I would update the players game to remove this asset!