What is your character? And what kind of game are you planning on making? I think your sprite's animation cells will have to have dimensions that are a power of 2. Maybe someone can jump in and correct me if I'm wrong though.
I'm pretty sure that If you use Unity's built-in sprite Atlasing tool than you don't have to worry about it. The resulting sprite Atlas will have a power-of-two and the sizes of the sprites in the atlas don't actually matter.